Published Clinical Research
A clinical study completed by OrthoXel in Cork University Hospital, Ireland, examined how the Apex Tibial Nailing System with micromotion fixation compares to the current standard of care (static locking) for treatment of tibial shaft fractures.
This study examined time to clinical union, incidence of delayed/nonunion and early integrity of new bones. Patients included a variety of fracture types, both open and closed, from high- and low-energy injuries.
Revision Case Series
A case series published in the Journal of Orthopaedic Reports describes patients who developed nonunion following primary intramedullary nailing and subsequently underwent revision with the Apex Tibial Nail featuring micromotion technology.
Treatment with the Apex micromotion nail, which provides enhanced torsional stability, resulted in successful fracture healing. All three patients achieved radiographic union (RUST ≥11) and full clinical recovery, despite a high-risk profile and previously persistent nonunion.
OTA Podcast
Sean Campbell, M.D., and Augustine Saiz, M.D., from UC Davis, California, joined Assoc. Prof. Hannah Dailey, OrthoXel’s Chief Scientific Officer, to discuss the challenges of tibial fracture healing and the role of controlled axial micromotion in patient outcomes on an episode of the OTA Podcast.
Drawing on both research and real-world cases, they examined mechanobiology, patient risk factors, nonunion concerns and shared their initial clinical experiences with the Apex Tibial Nailing System, where micromotion has shown clear benefits.
Clinical White Paper
Fracture Healing Following Delayed Weight Bearing
Building on the discussion from the OTA Podcast, Dr. Campbell collaborated with OrthoXel to develop this clinical white paper examining three challenging high-energy tibial fracture cases treated with the Apex Tibial Nailing System.
In this white paper, Dr. Campbell explores fracture healing following delayed weightbearing and discusses the potential interaction between controlled axial micromotion, progressive loading, and successful fracture union in complex injury patterns.
